For the complement system to cause AMD, there must be initiation (a ‘trigger’), amplification, and local retinal damage caused by the process. The alternative pathway of the complement system is ...

When drug development and the immune system collide we get CAR-T, checkpoint inhibitors, oncolytic vaccines, monoclonal antibodies and more. These fields have produced many therapies and garnered a ...

We are studying the role of the complement system in kidneys and brains during health and disease. Traditionally, major complement proteins were shown to be generated by the liver and are functional ...

Traumatic brain injury (TBI) is a major cause of disability and a risk factor for early-onset dementia. The injury is characterized by a physical insult followed acutely by complement driven ...

THE use of the complement-fixation test in serologic investigation serves as a frequent reminder to the physician of the existence of the complement system. It is probable that despite the advances ...

Global understanding of complement has shifted and developed since the 21st century: from our idea of a blood-based antibiotic system to a global regulator of immunity and tissue homeostasis. Recent ...

Immunotherapy is increasingly becoming standard therapy in cancer, with technology, such as checkpoint inhibitors and cell therapy, raising the efficacy bar in many forms of the disease. But the ...

Professor Riedemann's company was founded to translate complement system research into clinical applications, aiming to improve patient care. The pandemic shifted healthcare priorities, but focus is ...

Scientists have identified a persistent change in a handful of blood proteins in people with long Covid that indicates that an important part of their immune system remains on high alert for months ...