When most small-molecule drugs meet a protein target, they nestle close to their intended. But the flirtatious relationship between drug and target is often fleeting, with the drug repeatedly drifting ...

New research shows that curium — one of the heaviest known elements — can be manipulated to a larger degree than previously thought. An international team published a study on July 15 in the journal ...

One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 is targeted covalent inhibitors (TCIs). These small molecule drugs form covalent bonds with their ...

One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 are targeted covalent inhibitors (TCIs). These small molecule drugs form covalent bonds with their ...

Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...

Covalent chemical probes – chemical probes that form a covalent bond with their target biomacromolecule(s) represent powerful tools that can be used for biology discovery, target validation (or ...

Thousands of proteins are known to cause disease, but while the biological activity of these proteins is understood, the way to hit and modulate them with a drug is not. Nature still has ways to bind ...

Experimental evidence has confirmed earlier computational studies showing that the Au–C bonds in Au(CN) 2-have significant covalent character, in contrast to the ionic behavior of gold's lighter ...