In an age when the majority of monogenic human disease genes have been identified, one of the challenges for the coming generation of human geneticists will be to resolve complex polygenic and ...
. For about a century, the argument for focusing on rare Mendelian disorders was as follows: Mendelian phenotypes will reveal genes involved in common multifactorial traits, metabolic pathways ...
Many common health conditions arise due to a combination of genetic factors and lifestyle-related behaviors. People’s understanding of the multifactorial nature of health conditions has implications ...
Correspondence to Dr Sally Hopewell, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK; sally.hopewell{at}csm.ox.ac.uk Objective ...
Cardiovascular morbidity is a major burden in patients with type 2 diabetes. In the Steno-2 Study, we compared the effect of a targeted, intensified, multifactorial intervention with that of ...
In some cases, more than one factor may be responsible for causing the birth defect. For example genes form both parents may interact with one another to produce an undesirable effect in the presence ...
To what extent can our intestinal microbiota predict the risk of developing diseases? In the case of multifactorial diseases, bacterial taxa alone do not provide much information, according to a study ...
The pandemic of type 2 diabetes mellitus requires implementation of multifactorial interventions by clinicians for individual patients and policy makers for the health of the general public. In most ...
Recent analysis by GlobalData revealed that US hospital sales volumes of tests for popular STI targets decreased in the first half (H1) of 2025 versus H1 2024, with the reasons for the declines ...
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