Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 12 (Jun. 5, 2001), pp. 6935-6940 (6 pages) To investigate the molecular basis of the voltage sensor that ...
Real-time imaging of sub-cellular reactive oxygen species, Ca2+ signaling, and excitation-contraction coupling in skeletal muscle under physiological and pathophysiological conditions. The research in ...
The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...